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R424a Refrigerant | Drop-in replacement for R22 - 25 lb tank


Product Description

Call for Hot Deals On Bulk Pricing 1 800 300 2412

** Shipping Discounts **

** 2 Cylinders - Save $20 on shipping

** 4 Cylinders - Save $80 on shipping

** 6 Cylinders - Save $140 on shipping


Please see purchasing requirements for Wisconsin below.

Acme-Cool R424a Refrigerant    

25 Pound Cylinders       

Affordable and approved drop in replacement for R-22 refrigerant. Listed as an approved drop in replacement by the United States Environmental Protection Agency for use in systems operating with R-22 refrigerant.  Non-ozone depleting with performance and operating conditions similar to those of R-22 In a properly retrofitted R-22 system. Listed as a Non-Flammable refrigerant and approved for use in Retrofit and New Systems

Acme-Cool R424a provides similar cooling capacity, efficiency and thermodynamic properties to R-22 and exhibits an acceptable miscibility with both mineral and alkylbenzene lubricants typically used in R-22 systems. Most retrofits will not require an oil change unless there is an existing problem with oil return, in these cases where oil return is problematic a change to a POE lubricant is suggested.

R424a Refrigerant has been assigned an A1 rating by ASHREA. The A1 rating indicates that the refrigerant is both Non-Toxic and Non-Flammable. Despite the A1 rating we suggest that only qualified and trained technicians handle this or any other refrigerant. Available in 25 pound Non-Refillable Cylinder.  Acme-Cool R424a MSDS

Used in Europe for over a decade, R424a is a PROVEN R-22 replacement. Our R424a refrigerant is a true drop-in replacement and no system changes are required. Don’t worry about oil changes and rest assured R424a is good for cap tubes and TXV.  It operates at lower discharge pressure and temperature than R22, which is great for the compressor.


  • R424a is the approved R22 replacement drop-in refrigerant by Carrier Commercial. 
  • R424a operates in R22 systems without requiring an oil change to expensive synthetic oil.
  • R424a has the benefit of lower energy consumption. 
  • R424a operates at near capacity of R22. 
  • R424a operates at lower discharge pressure & temperatures thereby reducing compressor workload. 
  • R424a has been operating in all types of systems with all types of compressors worldwide for the past 10 years. No other R22 alternative refrigerant can make this claim. 

Type and Description

R424a is a direct replacement for R22, providing an easy and at the same time a long term solution. Because there is no need to use expensive and hygroscopic synthetic lubricants (POE), the risk of moisture ingress into a refrigeration system is completely avoided. R424a has significantly lower discharge temperatures and pressures than R22 which removes the problem of oil decomposition and improves the coefficient of performance and saves wear on the compressor.


R424a is suitable for use as a replacement for R-22 in existing residential, commercial and industrial air conditioning and refrigeration systems, and appliances.

Service Work

Because it is a blend, it is recommended that R424a be charged into systems as a liquid as opposed to the gaseous phase. Since there is no need to change the existing lubricant, R424a is straightforward to use, as the following procedure outlines.


R424a is compatible with both mineral and alkybenzene oils found in R22 systems, and also with the polyolester lubricants. Therefore, there is no need to change the lubricant although compressor manufacturers' recommendations regarding lubricity should be followed.

Materials Compatibility

R424a is compatible with all materials commonly used in refrigeration systems previously charged with R22. In general, materials which are compatible with R22 can be used with R424a. lt is recommended to check equipment manufacturer's retrofit literature and obtain recommendations from equipment manufacturers with regard to materials' compatibility.

Environmental Data

None of the components of R424a contains chlorine so that it has no ability to deplete the ozone layer.

As with all hydrofluorocarbons (HFCs), R424a does have a direct global warming potential (GWP), but this is counterbalanced by its lower Total Equivalent Warming Impact (TEWI). Tests have shown that R424a has a higher Coefficient of Performance (COP) than R22 in a range of applications including commercial refrigeration systems and heat pumps, both in the heating and cooling mode.

25 lb Cylinder R-424a Refrigerant

State Regulations govern the sale of  refrigerants. These products may only be sold to buyers that are properly certified by the Environmental Protection Agency (EPA)-approved testing program. We must require buyers to provide proof of EPA certification.
Purchasing alone is not proof of certification. 

Buyer must comply with ONE of the following: 

A. EPA Section #608 certified persons may purchase by emailing or faxing a copy of their certification card.  


B. A letter stating that the purchase is for resale purposes only.

Fax# 1-877-689-0333

Email: info (at) FrostyCool.com

Item will not ship unless all documentation is sent by buyer.


Frequently Asked Questions:

Q: Can I top off my system?  Can I mix refrigerants?  Do I have to evacuate my unit

A: Mixing refrigerants is ILLEGAL in North America. EPA regulations require that an Air-conditioning system be properly evacuated of refrigerant by a certified professional before replacing your refrigerant.

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Product Reviews

Write your own product review

  1. great alternative to R-22 5 Star Review

    Posted by on 9th Aug 2015

    Converted my heat pump system from R-22 due to a slow leak. Cost effective alternative to the expensive R-22. System now seems to run quieter and less frequently. Hot Texas 100+ degree summer has put it to the test and passesd.

  2. Worked as advertised 5 Star Review

    Posted by on 6th Aug 2015

    Had professionals install freon. I obtained MSDS and comparison data between R-22 and R242a (RS44) to assist installers, as they had no data on this new gas. All went well. I think the pros purged the R-22 before installing the new stuff, even tho product literature said the 2 gases were compatible.

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